Hope After HIV

GSK's commitment: Hope After HIV

In 2004, GlaxoSmithKline launched a project called "Hope After HIV: Africa." Through the Children's AIDS Fund (CAF), GlaxoSmithKline has helped open clinics in Uganda, Malawi, Zambia, and South Africa that have provided lifesaving care and treatment to more than 9,000 patients in communities devastated by HIV/AIDS.

The six sponsored clinics offer HIV tests to the community. Patients who test positive receive HIV medicines, education, mother-to-child transmission care, counseling, and follow-up. In addition to paid staff, patients are served by more than 1,500 volunteers who provide support, adherence counseling, disease education for family members, and palliative care.

GlaxoSmithKline has also established the Hope After HIV 501(c)(3) Fund, a charitable program that allows employees and others to donate funds to support life-enhancing, non-medical needs of patients receiving care at the clinics. For example, the fund has been used to:

• Provide crop seeds, chickens, and pigs to improve nutrition and generate income for patients and their families
• Donate a refrigerator for a new business
• Buy treadle pumps to help irrigate gardens during the dry season
• Pay school tuition and other education-related expenses for promising young people infected and affected by HIV
• Purchase ambulance bikes that transport patients who are too sick to walk or bike to a clinic for care

For more information on Hope After HIV or to contribute, please contact the Children's AIDS Fund.

See the full Prescribing Information for LEXIVA

LEXIVA^® (fosamprenavir calcium)

Indication and Usage:

LEXIVA treats HIV infection in adults. It should always be used in combination with other HIV medicines. These medicines do not cure HIV infection/AIDS or prevent passing HIV to others.

Important Safety Information

• You should not take LEXIVA if you have had an allergic reaction to LEXIVA or AGENERASE^® (amprenavir)
• High blood sugar, diabetes or worsening of diabetes, and bleeding in hemophiliacs have occurred in some patients taking protease inhibitors
• When you start taking HIV medicines, your immune system may get stronger and could begin to fight infections that have been hidden in your body, such as pneumonia, herpes virus, or tuberculosis. If you have new symptoms after starting your HIV medicines, be sure to tell your doctor
• Changes in body fat may occur in some patients taking antiretroviral therapy. The cause and long-term health effects of these conditions are not known at this time
• Skin rashes can occur in patients taking LEXIVA. Rarely, rashes were severe or life threatening
• Opportunistic infections can develop when you have HIV and your immune system is weak. It is very important that you see your healthcare provider regularly while you are taking LEXIVA to discuss any side effects or concerns
• Most common side effects in clinical studies were diarrhea, headache, nausea, rash, and vomiting. In most cases, these side effects did not cause people to stop taking their medicine

DRUG INTERACTIONS

• LEXIVA should not be taken with: AGENERASE^® (amprenavir), Halcion^® (triazolam), ergot medications (Cafergot^®, Migranal^®, D.H.E. 45^®, and others), Propulsid^® (cisapride), Versed^® (midazolam), Orap^® (pimozide), Zocor^® (simvastatin), Mevacor^® (lovastatin), Rifadin^® (rifampin), Rescriptor^® (delavirdine mesylate), or St. John's wort (Hypericum perforatum). If you are taking Norvir^® (ritonavir), you should not take Tambocor^® (flecainide), or Rythmol^® (propafenone hydrochloride)
• Serious and/or life-threatening events could occur between LEXIVA and other medications, including Cordarone^® (amiodarone), lidocaine (intravenous only), Elavil^® (amitriptyline HCl) and Tofranil^® (imipramine pamoate), tricyclic antidepressants, and Quinaglute^® (quinidine)
• Women who use birth control should choose a different kind of contraception. LEXIVA can affect the safety and effectiveness of birth control pills.
• Patients taking Viagra^® (sildenafil citrate) or LEVITRA^® (vardenafil HCl) with LEXIVA may be at an increased risk of side effects
• This list of drug interactions is not complete. Be sure to tell your healthcare provider about all medicines you are taking or plan to take, including over-the-counter drugs, vitamins, and herbals