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LEXIVA: Lab Abnormalities

Treatment-naive patients
<1% incidence of grade 3-4 hyperbilirubinemia and no jaundice or scleral icterus1


PI-experienced patients
No grade 3-4 hyperbilirubinemia and no jaundice or scleral icterus1


Treatment with LEXIVA/r has resulted in increases in the concentration of triglycerides. Triglyceride and cholesterol testing should be performed prior to initiating therapy with LEXIVA and at periodic intervals during therapy.
Caution should be exercised when administering LEXIVA to patients with hepatic impairment, including those with hepatitis B or C or marked elevation in transaminases prior to treatment. Increased AST/ALT monitoring should be considered in these patients.


Reference: 1. Data on file, GlaxoSmithKline.


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